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It is suggested that the engineered H3 tail does not confer a general functional advantage within the KRAB–DNMT3L–dCas9 architecture under the conditions tested.
Systematic comparison of Cas12i gene-editing tools in tomato identifies Cas-SF01 as the most efficient variant, achieving editing efficiencies comparable to conventional Cas9 at some genomic sites and providing a compact, highly specific, and versatile tool for studying gene function, engineering fruit metabolism, and...
This study establishes a versatile, gene‐editing‐empowered biomaterial platform that overcomes critical bottlenecks in cell therapy for central nervous system injuries and reduces cerebral edema and lesion volume in treated mice.
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