Author

Jian-Hua Zhou

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#gene editing Oct 2026

Programmable thermoregulation of the nuclease activity of LbCas12a.

CRISPR-Cas12a holds great promise for molecular diagnostics and gene editing due to its sequence-specific DNA recognition and robust trans-cleavage activity, yet precise tuning of its nuclease activity remains challenging. Herein, we report a simple temperature-regulation strategy using cost-effective ssDNA blockers, t...

Shi-Wen Tang, Xin-Yi Liao, Jun-Hong Chen et al. · Biosensors & bioelectronics · 0 citations

Sep 2026

An XNA-CRISPR Platform for PAM-Free Detection of the katG Ser315Thr Mutation Associated with Isoniazid Resistance in Tuberculosis

Drug-resistance Tuberculosis (TB) is a major threat to global public health. Simple and precise detection of the mutations associated with drug resistance is still a significant challenge. CRISPR-based nucleic acid detection has emerged as a transformative technology in molecular diagnostics due to its high specifici...

Xin-Yi Liao, Jun-Hong Chen, Yun-Zhu Wan et al. · Analytical Chemistry · 0 citations