Jessica Bourque

Comprehensive transcriptomic profiling uncovers an inflammatory maturation program conserved in human and mouse dendritic cells

Using Seqtometry-based analysis of mouse and human cDCs, distinct steady-state cDC1 gene programs enriched for either tolerance-associated or immune response-associated (pre-immunogenic) transcriptomic features that are present under homeostatic conditions in fully differentiated cDCs with divergent predicted immune fu...