OBJECTIVES
Understanding how obesity-associated genes function within defined neuronal subpopulations remains a major barrier to translating human genetics into pathophysiological mechanisms. Melanocortin-4 receptor-expressing (MC4R) neurons are key regulators of energy homeostasis and represent a potential site of act...
Major findings in the field of DNA methylation biology are described and how these findings have been utilized to build DNA methylation-based epigenome editors are described.
Danny Xu, A. E. Christenson, N. Phan et al.· Current Opinion in Chemical...· 0 citations
Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.
H. Ai, Frances H. Arnold, Doug Barrick et al.· Protein engineering, design...· 0 citations
A programmable method for transcriptional tuning in mammalian cells is presented and an orthogonal platform to dissect the mechanistic function of chromatin regulators in living cells is offered.
Jinna I. Brim, Izaiah J. Ornelas, Peter J. Colias et al.· bioRxiv· 0 citations
A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.
Hyuncheol Jung, Pascal Devant, Carter Ching et al.· Nature Biotechnology· 0 citations
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