Atypical MDM2 p53 Regulation and Chemosensitivity Induced by Proximal PAS Deletion
Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functional landscape of elongated 3'UTRs.
Minseo Kim, Celine Yoon, Jaewan Jun et al.
· bioRxiv · 0 citations