Serine MARylation (Ser-MARylation), catalyzed by poly(ADP-ribose) polymerase 1/2 (PARP1/2)-Histone PARylation factor 1 (HPF1) complex and reversed by ADP-ribosyl-acceptor hydrolase 3 (ARH3), is the primary form of DNA damage-induced ADP-ribosylation in human cells. Distinct from PARylation, Ser-MARylation represents a...
Prem Shrestha, Sharon Lin, Ainsley Lederer et al.· Journal of Biological Chemis...· 0 citations
The data support the development of the MYC/GSPT1 degrader GT19630 as a therapeutic strategy of MYC-driven hematologic malignancies as a therapeutic strategy of therapy-resistant hematologic malignancies.
Yuki Nishida, Valeria Impedovo, Edward Ayoub et al.· Blood· 0 citations
By integrating DDT inhibition with biomarkers like homologous recombination deficiency and tumor mutational burden, this work can drive synthetic lethality, sensitize tumors to genotoxic agents, suppress treatment-induced mutagenesis, and potentially enhance responses to immunotherapy.
Audesh Bhat, G. Lahane, R. Pandita et al.· Trends in Cancer· 0 citations
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