Author

J. Siveke

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Sep 2026

Abstract A027: Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

Loss of the Y chromosome (LOY) is a common somatic alteration in aging males and many cancer entities, yet its functional role in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We sought to determine whether LOY is a recurrent, functionally consequential event in male PDAC and to define its impact on tu...

M. Dorsch, Felix E. G. Beaudry, A. Baginska et al. · Cancer Research · 0 citations

#gene editing Sep 2026

Abstract B067: Dissection of the in vitro response landscape in PDAC under KRAS inhibition reveals co-occurring conserved and adaptive transcription programs

In vitro perturbation is used to decipher the early transcriptional response programs in patient-derived 2D and 3D cell models of PDAC to KRAS inhibition and identify a robust RNA-based signature with potential utility for pharmacodynamic monitoring and the study of adaptive resistance.

H. Schürmann, J. Asche, S. Liffers et al. · Cancer Research · 0 citations