J. Schneider

Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort.

DNA methylation (DNAm) plays a critical role in Alzheimer's disease (AD). Previous epigenome-wide association studies using 450K arrays captured limited CpG coverage and often focused on a single neuropathological measure. Here we profiled DNAm in 1,250 postmortem prefrontal cortex samples from the Rush Alzheimer's Dis...

Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study

MARBLE: An in vivo MRI marker of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC)

Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE‐NC) is common in older adults, yet definitive diagnosis is only possible at autopsy.

Alzheimer's disease heterogeneity and co‐pathologies: Defining novel targets, biomarkers, modalities, and research methodologies

Key takeaways from the Fall 2025 AARR meeting are presented, which brought together academic, clinical, and industry leaders to discuss and explore the current advances in the heterogeneity and co‐pathologies of AD and their implications for diagnosis, clinical trial design, and precision treatment strategies.

Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes

Differences in brain morphometry patterns when one or both pathologies are present remain unclear, yet differences in brain morphometry patterns when one or both pathologies are present remain unclear.

Cerebral amyloid angiopathy, brain iron concentrations, and cognitive decline in older people

It is suggested that brain iron may contribute to the clinical impact of CAA in older age and whether brain iron modulates the association of CAA with cognitive decline is investigated.