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J. Merl-Pham

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Open access Sep 2026

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

It is shown that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in livers of subjects with obesity and various mouse models of metabolic dysfunction, and that microRNAs from this cluster are critical regulators of metabolic homeostasis in the mature liver.

Manuel Gil-Lozano, E. Simoes, Mo-Ya Wu et al. · 0 citations
#gene editing Open access Sep 2026

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies

This work demonstrates how proteins created by generative artificial intelligence can be harnessed for the rational engineering of RNA transport systems with the desired properties by overcoming the limitations of natural protein diversity.

Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. R. Lang et al. · 1 citation

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