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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

J. Hurdle

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2 papers indexed here

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Review Open access Sep 2026

An integrated view of metabolic and physiological regulation of toxin production in Clostridioides difficile

ABSTRACT Clostridioides difficile is a leading cause of antibiotic-associated diarrhea, with pathogenesis driven primarily by the glucosylating toxins TcdA and TcdB. Traditionally, toxin gene expression has been explained through regulation of the pathogenicity locus by global transcriptional regulators that integrate...

Chetna Dureja, Ann M. McKelvey, J. Hurdle · 0 citations
Aug 2026

Development and validation of a novel LC-MS/MS method for simultaneous quantification of fidaxomicin and metabolite (OP-1118) from feces for gut pharmacobiome studies.

A novel LC-MS/MS method that was simple, fast, sensitive, and accurate in analyzing fecal fidaxomicin and OP-1118 and could be deployed to facilitate gut pharmacobiome research.

Chen-Lin Hu, Taryn A. Eubank, Ann M. McKelvey et al. · 0 citations

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