Clinically used opioids, such as morphine, primarily act through the μ-opioid receptor (MOR), encoded by the OPRM1 gene, which undergoes extensive alternative splicing. More than 20 OPRM1 isoforms have been identified, yet functional characterization has largely focused on the canonical MOR-1 variant. With the emergenc...
Michael Swingler, M. Donadoni, Senem Cakir et al.· Frontiers in Neuroscience· 0 citations
It is demonstrated that intact and potentially replication-competent virus persists in the primate brain under ART and that systemic AAV9-CRISPR can reach and edit proviral DNA in this sanctuary, supporting genome editing as a strategy toward durable remission of CNS reservoirs.
Hong Liu, Shu-Ren Liao, Chen Chen et al.· Molecular Therapy: Nucleic A...· 1 citation
The combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an ex vivo cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies.
Z. Safaei, Anna Bellizzi, Hong Liu et al.· Human Gene Therapy· 0 citations
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