Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.
Rosemary B. Kirk, C. Santiago, Hugh Watkins et al.
· Nature Cardiovascular Resear... · 0 citations
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Open access
Jul 2026
Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics
SVIL-associated cardiomyopathy is established as a mechanistically distinct form of HCM and drugs targeting mitochondrial bioenergetics may be a therapeutic strategy in patients with SVIL-associated cardiomyopathy.
Yifan J. Li, Y. Psaras, V. Steeples et al.
· bioRxiv · 0 citations