#gene editing
Sep 2026
Coupling continuous directed evolution with base editors identifies combinatorial antibiotic resistance
The adaption of the continuous directed evolution (CDE) along with base editor (BE) gene editing strategy to discover TEM-1 mutants is reported here and highlights the application of gene editing methods to provide insight into the molecular basis of antibiotic resistance.
Hong Wang, Jia-Mei Wang, Ding-Jue Zhang et al.
· Biotechnology Letters · 0 citations