Discovery of dietary polyphenols targeting the autoinducer-2 quorum sensing system of pathogenic bacteria.
Targeting autoinducer-2 (AI-2) quorum sensing (QS) systems with dietary compounds represents a promising strategy to combat pathogens, yet mechanisms remain elusive. Here, we develop a machine learning-driven framework combining computational screening with multi-level experimental analysis to identify AI-2 quorum sens...
Sheng-Bo Wu, Peng Zhang, Man-Man Wang et al.
· Gut microbes · 0 citations