Hiroki Shimizu

P1.109. Overexpression of RFC3 Relates to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma

Esophageal Cancer: Molecular Biology/Pathology Replication factor C (activator 1) 3 (RFC3), located on 13q13.2, is reported to be necessary for the elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon. In this study, we tested whether RFC3 acts as a cancer-promoting factor...

[Overexpression of JMJD6 Drives Immune Evasion via the BRD4-IRF1-PD-L1 Axis and Promotes Malignancy in Gastric Cancer].

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Esophageal Cancer: Molecular Biology/Pathology Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remains unclear. We aimed to identify a PD-L1–targe...

Low circulating miR-5193 promotes PD-L1-mediated immune evasion and relates to immune checkpoint inhibitor response in esophageal cancer

Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remains unclear. We aimed to identify a PD-L1-targeting tumor-suppressor microRNA downregulated in esophageal squamous...