Author

Hanqian L. Carlson

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Sep 2026

CSF3R compound mutations produce a hyperproliferative leukemia driven by overexpression of PIM kinases.

Colony Stimulating Factor 3 Receptor (CSF3R) mutations are the molecular hallmark of chronic neutrophilic leukemia (CNL). A subset of these patients (~25%) have two mutations in CSF3R on the same allele. These "compound" CSF3R mutations include both an activating point mutation and a cytoplasmic truncating mutation. Wh...

Breanna N. Maniaci, Jacob Edward Porter, Hanqian L. Carlson et al. · Blood · 0 citations

#gene editing Open access Sep 2026

Mutant ASXL1 Cooperates with MECOM and BRD4 to Drive Transcriptional Dysregulation in Human Hematopoiesis.

Mutations in the epigenetic regulator ASXL1 are common in myeloid malignancies and portend a near-universally poor prognosis. While multiple mechanisms for mutant ASXL1-dependent oncogenesis have been proposed, none have been functionally validated in the context of the human hematopoietic stem cell, where these mutati...

Madison L. Hall, Aliya Quintal, Sonia N. Acharya et al. · Blood · 0 citations