Author

Goo Jang

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Open access Oct 2025

Mutation-agnostic base editing of the progerin farnesylation site rescues Hutchinson-Gilford progeria syndrome phenotypes in neuromuscular organoids

Hutchinson Gilford progeria syndrome (HGPS) is a fatal premature aging disorder caused by pathogenic farnesylated lamin A variants that disrupt nuclear architecture and DNA repair. Current therapies, including farnesyltransferase inhibitors, provide only modest survival benefits and lack molecular specificity, while mu...

Dong-Woo Kim, Eun-Ji Kwon, Beom-Jin Jeon et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

Safe and Stable Germline Transmission of MSTN Mutations in Cattle

ABSTRACT With the global population expected to reach 10 billion by 2050, sustainable livestock production is critical. Gene editing of the myostatin (MSTN) gene represents a promising strategy to enhance muscle growth in cattle. In this study, MSTN‐mutated founder (F0) cows were used to generate F1 offspring via ovum...

G. Gim, Bae Young Choi, Jeongbin Yi et al. · Animal Genetics · 0 citations

Aug 2026

Evaluation of germline transmission of electroporation-mediated double gene-edited cattle lines.

Gene editing in livestock using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) offers a promising approach for genetic improvement in cattle. This study evaluated germline transmission and mutation stability of double-knockout cattle generated by zygote electroporati...

Kyeong-Hyeon Eom, G. Gim, Min-Gyu Lee et al. · Theriogenology · 0 citations