Chemical exposure during human development, especially in utero, can disrupt many biological processes and increase disease vulnerability. Assessing the chemical landscape across the maternal–fetal interface is challenging. Here we address this challenge by conducting an exposome-based analysis across a suite of integr...
M. Marquès, R. Gil-Solsona, Ana González-Ruiz et al.· Environmental Science and Te...· 0 citations
Abstract INTRODUCTION Environmental exposures contribute substantially to Alzheimer's disease and related dementias (ADRD), yet comprehensive exposome‐wide investigations systematically evaluating multi‐domain environmental factors remain limited and lacking utility for precision medicine. METHODS We conducted an expos...
Chen-Shuang Li, Chen-Xu Zhao, Yi-Qun Lan et al.· Alzheimer's & Dementia· 0 citations
An AI-enhanced virtual screening pipeline delivered selective SV2C ligands from a general chemical library, providing tools to probe SV2C biology in Parkinson’s disease.
Alexander C. Brueckner, Matthew F. Martin, Sheenam Khuttan et al.· bioRxiv· 0 citations
Radon is a radioactive gas and a lung carcinogen, yet lacks established blood biomarkers for long-term exposure. We aimed to identify circulating metabolomic and exposomics signatures correlated with reconstructed radon-222 exposure. Metabolites and chemical exposomes were profiled using liquid and gas chromatography-h...
Vrinda Kalia, A. Rajendrakumar, Rodrigo Cruz-Nieto et al.· Environmental Research· 0 citations
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