Background Leukocyte’s role in frequently occurring right ventricular dysfunction (RVD) secondary to HFpEF remains poorly defined, partially due to the lack of suitable small animal models. Here, we followed a translational research approach by establishing a murine HFpEF model developing manifest RVD and analyzed huma...
L. Jaeschke, C. Koçana, A. M. Chitroceanu et al.· Circulation· 0 citations
Heart failure with preserved ejection fraction (HFpEF) prevalence is increasing in Asia, driven by aging populations and rising cardiometabolic risk. Asian patients with HFpEF present a decade earlier than Western counterparts, carry a disproportionate burden of diabetes, chronic kidney disease, and visceral adiposity...
Jasper Tromp, T. Teng, Wan T. Tay et al.· JACC: Asia· 0 citations
Mechanistically, visceral adiposity, systemic inflammation, immunometabolic dysregulation, structural remodeling, and accelerated cardiac aging converge to drive HFpEF across Asian patients, often at lower body mass index thresholds than recognized in Western models.
E. Balasa, F. Capone, A. Vacca et al.· 0 citations
Mechanistically, visceral adiposity, systemic inflammation, immunometabolic dysregulation, structural remodeling, and accelerated cardiac aging converge to drive HFpEF across Asian patients, often at lower body mass index thresholds than recognized in Western models.
E. Balasa, F. Capone, A. Vacca et al.· JACC: Asia· 0 citations
BACKGROUND
While metabolic dysfunction-associated steatotic liver disease (MASLD) has been consistently associated with increased cardiovascular risk in the general population, its association with cardiovascular disease (CVD) mortality in adults with established cardiometabolic risk factor (including obesity, hyperten...
Ruoting Wang, Wenli Li, J. Lazarus et al.· Cardiovascular Diabetology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
