This review summarizes how AI is reshaping neoantigen discovery, from somatic variant calling, HLA typing, and peptide processing to peptide–MHC binding, presentation, and T cell recognition, and demonstrates that integrating features of antigen processing, presentation, and TCR recognition can eliminate the majority of non-immunogenic candidates while retaining clinically relevant neoepitopes.
Atefeh Bakhshian, Sajjad Ghorghanlu, Fereshteh Fallah Atanaki et al.· Journal of Translational Med...· 0 citations
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