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Author

G. Elshopakey

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Open access Sep 2026

Icariin-loaded liposomal nanoparticles alleviate streptozotocin-induced diabetic hepatopathy associated with modulation of ferroptosis-related and inflammatory signaling

Diabetic hepatopathy is a major complication of type 2 diabetes mellitus characterized by metabolic dysregulation, oxidative stress, inflammation, and emerging evidence of ferroptosis-mediated liver injury. Icariin (IC), a bioactive flavonoid, exhibits hepatoprotective potential; however, its clinical applicability is...

B. Hifni, S. A. Alyamani, Nasser S. Alqahtani et al. · 0 citations
Open access Sep 2026

PLGA-loaded puerarin attenuates arsenic-induced liver injury through modulation of ferroptosis, oxidative stress, inflammation, and apoptotic signaling

Arsenic (AR) is an environmental and mining occupational toxicant with reported hepatotoxic effects. Ferroptosis has recently emerged as a critical mechanism involved in arsenic-induced hepatotoxicity. This study investigated the hepatoprotective effects of puerarin (PU) and its PLGA-loaded nanoparticle formulation (PU...

S. A. Alyamani, B. Hifni, Nasser S. Alqahtani et al. · 0 citations
Open access Aug 2026

Dietary Roselle (Hibiscus sabdariffa) Against Tebuconazole Exposure in Oreochromis niloticus: Growth, Digestive Enzymes, Intestinal Transporters, Inflammatory/Apoptotic Genes, and Histological Assays.

Fish health and the sustainability of aquaculture are seriously threatened by exposure to agricultural fungicides. Thus, the current study intended to assess how dietary roselle (Hibiscus sabdariffa) extract (ROS) protects Nile tilapia (Oreochromis niloticus) from tebuconazole (TEB)-induced toxicity. Fish (n = 160; 20....

Rowida E. Ibrahim, G. Elshopakey, Abdallah Tageldein Mansour et al. · 0 citations
Open access Sep 2026

Liposomal Morin Attenuates DMH-Associated Colonic Oxidative Stress, Inflammation, and Apoptosis/Autophagy-Related Dysregulation in Rats

Background/Objectives: Oxidative stress, chronic inflammation, disrupted apoptosis, and altered autophagy are biological processes implicated in colorectal tumor development. Morin is a plant-derived flavonoid with antioxidant and anti-inflammatory properties, but its limited solubility and bioavailability may limit it...

Mohammed A. Akeel, E. Elmorsy, F. Alshammari et al. · 0 citations
Open access Aug 2026

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...

Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al. · 0 citations
Jul 2026

Recuperative efficacy of Amphora coffeaeformis-enriched diet on immunotoxicological, hematobiochemical alterations, oxidative stress, proinflammatory genes disorder, and histopathological changes caused by cypermethrin toxicity in Nile tilapia.

This work investigates the potential protective effects of the diatom Amphora coffeaeformis as a feed additive against the deleterious effects (primarily on immune organs) of cypermethrin (CYP) in Nile tilapia, Oreochromis niloticus, with respect to hematology, immune/antioxidant parameters, biochemical indices, proinf...

Elsayed A. A. Eldessouki, G. Elshopakey, Mai A. M. El‐Son et al. · 0 citations
Aug 2026

Dietary banana peels modulate waterborne oxyfluorfen-induced hepatotoxicity in Nile tilapia (Oreochromis niloticus) via regulation of redox homeostasis and ER stress signaling

Overall, BPP (20 g/kg) may protect O. niloticus against OXY-induced liver damage through its antioxidant potential, supporting its application as a functional additive in aquaculture.

Afaf N. Abdel Rahman, G. Elshopakey, A. Mansour et al. · 0 citations

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