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Author

Friederike Reinhardt

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#protein folding Open access Oct 2026

De novo design of light-controlled conformational protein switches

Light-responsive proteins offer the ability to control biology at an unmatched resolution. Yet, optogenetics is limited to a relatively small number of natural and engineered photoreceptors. The design of light-responsive proteins with native-like complexity is challenging as they must incorporate a light-responsive ch...

Alexander T. Hilditch, N. Goldbach, Chen-Xuan Liu et al. · 0 citations
#gene editing Open access Sep 2026

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies

This work demonstrates how proteins created by generative artificial intelligence can be harnessed for the rational engineering of RNA transport systems with the desired properties by overcoming the limitations of natural protein diversity.

Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. R. Lang et al. · 1 citation

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