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Author

Francisco J. Sánchez-Rivera

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#gene editing Oct 2026

Abstract C131: Influences of ancestry-associated non-pathogenic germline variants as cancer vulnerabilities

The advent of precision oncology has transformed cancer care. Yet only approximately 25% of patients are eligible for targeted therapies, as current approaches exploit tumors harboring well-characterized somatic driver alterations. This limitation has restricted the broader clinical impact of precision medicine and c...

Nicole Peiris, Sean A. Misek, Angela Chen et al. · 0 citations
Open access Jul 2026

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.

Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al. · 0 citations

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