Author

Fengqing Wang

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Aug 2026

Alleviating the Crabtree Effect for High-Level Production of Squalene in Saccharomyces cerevisiae.

Saccharomyces cerevisiae is a widely used biomanufacturing chassis; however, its inherent Crabtree effect severely limits energy yield and diverts carbon flux away from the desired non-ethanol products. To address this challenge, we developed a multidimensional metabolic engineering strategy to alleviate the Crabtree e...

Shuyan Tang, Wenzhuo Gao, Jia-Ying Wang et al. · Metabolic Engineering · 1 citation · ⚡1

Open access Sep 2026

Antibiotic- and inducer-free biosynthesis of indican from crude glycerol using engineered probiotic Escherichia coli Nissle 1917

Chemical synthesis of indigo relies on aniline and formaldehyde feedstocks, inevitably generating carcinogenic byproducts and imposing severe environmental burdens, driving the urgent demand for sustainable bio-manufacturing alternatives. As a water-soluble glycoside precursor of indigo, indican circumvents the cytotox...

Li-Jing Mao, Jia-Qi Su, Yu Mo et al. · Bioresources and Bioprocessi... · 0 citations

Open access Sep 2026

Biomanufacturing of 2-Pyrone-4,6-dicarboxylic Acid by an Engineered Corynebacterium glutamicum Cell Factory

2-Pyrone-4,6-dicarboxylic acid (PDC) is a promising pseudo-aromatic bio-based monomer for the production of biodegradable polyesters. Here, we combined metabolic engineering with fermentation process optimization to establish efficient de novo PDC biosynthesis in Corynebacterium glutamicum. To enhance the availability...

Meng Chai, Rui-Tao Yu, Yi-Tong Li et al. · Fermentation · 0 citations