Author

Feixiong Cheng

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#gene editing Open access Oct 2026

Interferon-induced OASL restricts ADAR1 p150 RNA binding and A-to-I RNA editing

The interferon (IFN)-inducible RNA editor ADAR1 p150 catalyzes adenosine-to-inosine (A-to-I) editing of host and viral double-stranded RNAs, limiting aberrant innate immune sensing and regulating gene expression. How ADAR1 p150 activity is regulated during host-virus interactions remains poorly understood. Here, we ide...

Stephanie Leon Quinonez, Amit Gupta, Soowon Kang et al. · bioRxiv (Cold Spring Harbor... · 0 citations

#protein folding Open access Sep 2026

Catechol-O-methyltransferase connects dopamine homeostasis to redox signaling, metal homeostasis, and protein folding in schizophrenia.

Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavi...

S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al. · Proceedings of the National... · 0 citations