A conserved lncRNA-PA1-MLL3/4-Foxo3 epigenetic axis that drives enhancer reprogramming and a self-reinforcing Foxo3 circuit is uncovered and is positioned as a promising therapeutic target and its human homolog as a circulating biomarker for AKI.
Rui-Zhi Tan, Jian Jia, Qiu-Xiang Bai et al.· International Journal of Bio...· 0 citations
Overall, this review highlights the promise of epigenetics-based therapeutic strategies using herbal active ingredients for kidney disease intervention, though further validation and optimization are needed for clinical application.
Qiu-Xiang Bai, Kang Luo, Long-hao Jia et al.· Seminars in Nephrology· 0 citations
An emerging paradigm shift toward third-generation, multi-lineage, and immune-competent vascular organoids is synthesized, with emphasis on fluidic shear stress in microfluidic platforms, the spatial precision afforded by three-dimensional bioprinting, and multiplex CRISPR gene editing.