Blood-based proteomics is approaching a translational inflection point. Driven by advances in measurement technologies, rapid expansion of analytical capabilities, and growing adoption across research and medical communities, there is increasing demand for clinically actionable biomarkers. As the field transitions away...
Sara Ahadi, H. Babačić, Lee S. Cantrell et al.· Journal of Proteome Research· 0 citations
Circulatory proteome is a promising tool to capture distinct tissue-specific responses that correlate with disease activity and tissue injury in patients with IIM.
Yue-Bei Luo, J. Kenrick, A. Galindo-Feria et al.· Arthritis & Rheumatology· 0 citations
Reading a protein’s sequence from tandem mass spectra without a reference is limited by single-spectrum accuracy, most acutely across the hypervariable complementaritydetermining regions of antibodies. Broadly specific proteases tile a protein with long, overlapping peptides, so every residue is covered by many indepen...
Alfred Nilsson, Emil Sporre, Douwe Schulte et al.· bioRxiv· 0 citations
Cell-type enrichment analysis indicating a broad cellular origin of the circulating proteome, with contributions from nervous system cells, vascular cells, immune cells, and muscle cells, highlights the potential of plasma proteomics for clinically meaningful patient stratification in ALS.
I. Aksoylu, L. Azizi, L. OÌijerstedt et al.· medRxiv· 0 citations
The importance of a pan-disease approach to identify robust and disease-informative protein panels for improved classification of SARDs is demonstrated and disease-specific proteins that differentiate systemic autoimmune rheumatic diseases are identified.
J. Kenrick, C. Preger, M. B. Álvez et al.· Communications Medicine· 2 citations
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