Open access
Sep 2026
A single-nucleus multi-omic atlas comprising 459,856 transcriptomic and chromatin accessibility profiles from 21 adult human tissues across four donors, including paired measurements from 160,688 nuclei is presented.
Kai-Li Fan, Amrita Sule, A. Guillaumet-Adkins et al.
· bioRxiv · 0 citations
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Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances1-8. Yet the mechanisms by which HbF expression is activated remain incompletely understood9. Here we conduct a large multi-ancestry genome-wide association study of HbF levels...
Chun-Jie Guo, U. Arora, Xiao-Heng Cheng et al.
· Nature · 0 citations
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Open access
Jul 2026
This work fine-mapped UK Biobank-derived genome-wide association study (GWAS) signals from 164 traits and identified e/sQTL colocalizations for 10,611 GWAS signals, including 7096 that colocalize with secondary e/sQTLs.
Peter Orchard, T. Blackwell, L. Kachuri et al.
· Science · 0 citations
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Open access
Aug 2026
C. Yang, F. Aguet, G. Auguste et al.
· medRxiv · 0 citations
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