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E. Goldys

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#gene editing Open access Oct 2026

A light-responsive lipid nanoparticle platform delivering Cas9 RNP for VEGFA editing suppresses choroidal neovascularisation

This study developed lipid-based nanoparticles to release Cas9/sgRNA ribonucleoprotein (RNP) complexes under light illumination, enabling light-controlled editing of the VEGFA gene, providing a foundation for spatially controlled VEGFA genome editing as a potential therapeutic strategy for VEGFA-driven macular neovascu...

Rui Sang, Xin-Pu Yang, Ewa M. Goldys et al. · 0 citations
#gene editing Aug 2026

Light- and X-ray-Activated Liposomes for Controlled Gene Editing and Drug Delivery.

This protocol presents methods for fabricating and characterising two distinct verteporfin (VP)-integrated lipid nanoparticle formulations and demonstrates knockout of up to approximately 326 slow-muscle fibres per zebrafish embryo via light activation and significant tumour growth suppression via X-ray-triggered doxor...

Yagiz A. Aksoy, Biyao Yang, G. Liew et al. · 0 citations

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