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Author

Elham Erfani Ezadyar

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Review Open access Jul 2026

AI-driven neoantigen identification: a comprehensive review from somatic variant calling to T cell recognition

This review summarizes how AI is reshaping neoantigen discovery, from somatic variant calling, HLA typing, and peptide processing to peptide–MHC binding, presentation, and T cell recognition, and demonstrates that integrating features of antigen processing, presentation, and TCR recognition can eliminate the majority of non-immunogenic candidates while retaining clinically relevant neoepitopes.

Atefeh Bakhshian, Sajjad Ghorghanlu, Fereshteh Fallah Atanaki et al. · 0 citations

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