Elamathi Natarajan

In Silico Design and Evaluation of CRISPR Cytosine Base Editing Strategy for Potential Correction of the ASPA Variant Associated with Canavan Disease

A candidate sgRNA with favourable predicted editing characteristics and genome-wide specificity for potential CBE-mediated correction of the ASPA c.691T>C (p.Tyr231His) variant is identified and a rational framework for prioritizing this guide for experimental evaluation is provided.

Cross-Dataset Reanalysis of Mouse Alzheimer Disease Single-Cell RNA-Sequencing Data Reveals a Reproducible Innate Immune Activation Signature

Deciphering the Tumor Microenvironment: An Integrated Single-Cell RNA-Seq and AI Framework for Novel Biomarker and Therapeutic Target Discovery in Melanoma

The discovery of the protective prognostic role of CD79A links single-cell immune networks directly to clinical patient outcomes, providing a reproducible roadmap for anti-tumour immune engagement and immunotherapeutic stratification.