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Author

E. Martín-Guerrero

2 papers indexed here

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Review Open access Sep 2026

Bone Aging and Glycative Stress: Convergent and Divergent Mechanisms Driving Skeletal Deterioration

Aging and glycative stress are major, interrelated drivers of skeletal fragility, yet the extent to which they act through shared versus distinct biological pathways remains poorly defined, limiting integrated therapeutic strategies. This review compares the convergent and divergent mechanisms by which aging and glycat...

Salvador Peñarrubia, E. Martín-Guerrero, A. Gortázar et al. · 0 citations
#gene editing Open access Oct 2026

Generation and Characterization of an Osteoclastic Cell Model of Gaucher’s Bone Disease

Gaucher disease (GD) is caused by recessive mutations in the GBA1 gene (Glucosylceramidase beta 1) generating lysosomal accumulation of glucosylceramides. Bone phenotypes related to GD include Erlenmeyer flask deformity, osteosclerosis, osteonecrosis, osteopenia, and bone pain. Lysosomes modulate osteoclast differentia...

J. Patiño-Salazar, J. D. Gutiérrez-Ávila, S. Heredero-Jiménez et al. · 0 citations

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