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E. Elmorsy

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Open access Aug 2026

Hesperetin-Loaded PLGA Nanoparticles Ameliorate Cisplatin-Induced Oxidative Stress and Testicular Dysfunction in Rats: Association with NRF2/HO-1, NF-κB, and ACSL4/GPX4/SLC7A11 Signaling Modulation

HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...

Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al. · 0 citations
Open access Jul 2026

Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis

It is demonstrated that NG and HP could protect ovarian granulosa cells from CIS-induced damage through dual regulation of the Nrf2/heme oxygenase-1 (HO-1) antioxidant and nuclear factor kappa B (NF-κB) inflammatory axis, highlighting their potential as adjuvant therapies to mitigate chemotherapy-induced ovarian toxici...

Ahmed Abdeen, Obeid Shanab, Mohammed H. Hassan et al. · 0 citations
Open access Jul 2026

Protective Effects of Limonene and a Nano-Liposomal Limonene Formulation Against Chlorfenapyr-Induced Renal Toxicity: Mechanistic Insights into NRF2/HO-1 and NF-κB/COX-2 Signaling, Mitochondrial Dysfunction, and Apoptosis in Rat Kidneys

Overall, nano-liposomal delivery enhanced the renoprotective efficacy of limonene, highlighting its potential as a therapeutic strategy against pesticide-induced kidney injury.

E. Elmorsy, Amina A. Farag, Amal M. Abdel-Kareim et al. · 0 citations
Aug 2026

Enhanced hepatoprotective effects of fisetin-loaded liposomal nanoparticles against DEHP-induced liver injury in rats: modulation of oxidative stress, inflammation, apoptosis, and ferroptosis pathways.

FSN-LNPs provided enhanced hepatoprotection against DEHP-induced toxicity compared with free FSN, which was associated with attenuation of oxidative stress and inflammation and modulation of apoptosis- and ferroptosis-related pathways, likely due to improved bioavailability and cellular delivery.

Ahmed Al-Emam, Hesham M. Hassan, E. Elmorsy et al. · 0 citations
Aug 2026

Protective Effects of Icariin-Loaded Nanoliposomes against Methotrexate-Induced Testicular Toxicity via Modulation of NRF2/NF-κB and Ferroptosis Signaling.

ICA-loaded nanoliposomal formulation effectively attenuated MTX-induced testicular toxicity and was associated with reduced oxidative stress, inflammation, apoptosis, and ferroptosis, highlighting its potential as a promising therapeutic strategy for preserving male reproductive function.

Ahmed Al-Emam, Salim Jamil, Hesham M. Hassan et al. · 0 citations
Open access Jul 2026

Nano‐Rosmarinic Acid Protects Against Chlorfenapyr‐Induced Testicular Toxicity Through Modulation of NRF2/HO‐1 and NF‐κB/NLRP3 Signaling Pathways

Overall, RA‐loaded Chitosan nanoparticles provided superior protection against CFP‐induced testicular toxicity compared with crude RA, highlighting the potential of nanoformulation strategies to enhance RA's biological efficacy.

Ahmad Najem Alshammari, Ayat B. Al-Ghafari, H. A. Al Doghaither et al. · 0 citations

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