HES and HES-PLGA-NPs were associated with multi-mechanistic protection against cisplatin-induced oxidative, inflammatory, apoptotic, and ferroptosis-associated damage in the testes, and may represent a promising nanoantioxidant candidate warranting further investigation for preserving male reproductive function during...
Mohammed A. Akeel, E. Elmorsy, Aly A. M. Shaalan et al.· Antioxidants· 0 citations
It is demonstrated that NG and HP could protect ovarian granulosa cells from CIS-induced damage through dual regulation of the Nrf2/heme oxygenase-1 (HO-1) antioxidant and nuclear factor kappa B (NF-κB) inflammatory axis, highlighting their potential as adjuvant therapies to mitigate chemotherapy-induced ovarian toxici...
Ahmed Abdeen, Obeid Shanab, Mohammed H. Hassan et al.· Frontiers in Pharmacology· 0 citations
Overall, nano-liposomal delivery enhanced the renoprotective efficacy of limonene, highlighting its potential as a therapeutic strategy against pesticide-induced kidney injury.
E. Elmorsy, Amina A. Farag, Amal M. Abdel-Kareim et al.· Toxics· 0 citations
FSN-LNPs provided enhanced hepatoprotection against DEHP-induced toxicity compared with free FSN, which was associated with attenuation of oxidative stress and inflammation and modulation of apoptosis- and ferroptosis-related pathways, likely due to improved bioavailability and cellular delivery.
Ahmed Al-Emam, Hesham M. Hassan, E. Elmorsy et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
ICA-loaded nanoliposomal formulation effectively attenuated MTX-induced testicular toxicity and was associated with reduced oxidative stress, inflammation, apoptosis, and ferroptosis, highlighting its potential as a promising therapeutic strategy for preserving male reproductive function.
Ahmed Al-Emam, Salim Jamil, Hesham M. Hassan et al.· Reproductive Toxicology· 0 citations
Overall, RA‐loaded Chitosan nanoparticles provided superior protection against CFP‐induced testicular toxicity compared with crude RA, highlighting the potential of nanoformulation strategies to enhance RA's biological efficacy.
Ahmad Najem Alshammari, Ayat B. Al-Ghafari, H. A. Al Doghaither et al.· Journal of biochemical and m...· 0 citations
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