E. Elmorsy

Nano-Diosmin mitigates EAC-induced renal injury through Nrf2-mediated antioxidant activation and NF-κB-dependent apoptotic suppression

Chrysin preserves renal structure and mitochondrial quality control in D-galactose-induced kidney aging: enhanced efficacy via nano-encapsulation.

Icariin-loaded liposomal nanoparticles alleviate streptozotocin-induced diabetic hepatopathy associated with modulation of ferroptosis-related and inflammatory signaling

Diabetic hepatopathy is a major complication of type 2 diabetes mellitus characterized by metabolic dysregulation, oxidative stress, inflammation, and emerging evidence of ferroptosis-mediated liver injury. Icariin (IC), a bioactive flavonoid, exhibits hepatoprotective potential; however, its clinical applicability is...

Chrysin-loaded casein nanoparticles protect against chlorfenapyr-induced renal injury through modulation of Nrf2/HO-1, NF-κB, and mitochondrial bioenergetics.

BACKGROUND Chlorfenapyr (CFP) is a pesticide that induces nephrotoxicity through oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Casein nanoparticles may enhance the therapeutic efficacy of chrysin (CY). OBJECTIVE This study evaluated the protective effects of free CY and chrysin-loaded case...

Chrysin-Loaded Casein Nanoparticles Protect Against Sepsis-Associated Acute Kidney Injury via Activation of Nrf2/HO-1 and Suppression of TLR4/NF-κB Signaling

PLGA-Encapsulated Pterostilbene Mitigates Cadmium-Induced Nephrotoxicity in Rats by Modulating Oxidative Stress, Inflammation, and Apoptosis

Cadmium (Cd) is an environmentally pervasive toxic metal that accumulates in the kidney and promotes oxidative stress, inflammation, and apoptosis. This study evaluated the renoprotective effects of free pterostilbene (PTS) and PLGA-encapsulated PTS (PTS-PLGA) in male Sprague–Dawley rats with Cd-induced nephrotoxicity....

Gallic Acid-Loaded Chitosan Nanoparticles Mitigate Methomyl-Induced Nephrotoxicity in Rats: Associations with Oxidative Stress, Inflammation, and Apoptotic Signaling

PLGA-loaded puerarin attenuates arsenic-induced liver injury through modulation of ferroptosis, oxidative stress, inflammation, and apoptotic signaling

Arsenic (AR) is an environmental and mining occupational toxicant with reported hepatotoxic effects. Ferroptosis has recently emerged as a critical mechanism involved in arsenic-induced hepatotoxicity. This study investigated the hepatoprotective effects of puerarin (PU) and its PLGA-loaded nanoparticle formulation (PU...

Liposomal Honokiol Nanoparticles Attenuate Manganese-Induced Hippocampal Neurotoxicity via NRF2/HO-1 and SIRT1/PGC-1α Pathways: Association with Oxidative Stress, Neuroinflammation, Mitochondrial Dysfunction, and Apoptosis

Highlights What are the main findings? Manganese exposure is associated with hippocampal oxidative stress, mitochondrial dysfunction, neuroinflammation, neurotransmitter imbalance, and apoptosis, with structural neuronal damage in rats. Liposomal honokiol nanoparticles are associated with reversal of Mn-induced alterat...

Nanoliposomal curcumin protects against D-galactose-induced hepatic aging by targeting oxidative stress, mitochondrial dysfunction, and inflammatory signaling.

CUR, especially in its nanoliposomal form, exerts potent hepatoprotective, antioxidant, anti-inflammatory, and anti-apoptotic effects against D-galactose-induced liver aging, supporting its potential as a therapeutic strategy for age-related hepatic dysfunction.

Hepatoprotective effects of carvacrol nano-phytosomes against lead toxicity: Restoration of tissue architecture via NF-κB/NLRP3 suppression and antioxidant enhancement.

The objective of the current study was to assess the hepatoprotective properties of nano-phytosomes (CRV-PNPs) loaded with carvacrol (CRV) in response to lead (Pb)- triggered liver injury. Male Wistar rats were assigned to six groups: Control, CRV, CRV-PNPs, Pb, Pb/CRV, and Pb/CRV-PNPs. Pb intoxication led to considera...

Liposomal Morin Attenuates DMH-Associated Colonic Oxidative Stress, Inflammation, and Apoptosis/Autophagy-Related Dysregulation in Rats

Background/Objectives: Oxidative stress, chronic inflammation, disrupted apoptosis, and altered autophagy are biological processes implicated in colorectal tumor development. Morin is a plant-derived flavonoid with antioxidant and anti-inflammatory properties, but its limited solubility and bioavailability may limit it...