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Author

E. Bandala-Sanchez

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#gene editing Open access Jul 2026

Prime editing enables drug-controllable T-cell therapies with clinical immunosuppression.

A multiplex prime-editing platform is developed that converts commonly used immunosuppressive drugs into tools for in vivo control of T-cell therapies via defined, pathway-specific drug resistance, enabling selective in vivo modulation in settings where immunosuppression cannot be withdrawn.

E. Bandala-Sanchez, Emma V. Petley, K. Ramsay et al. · 0 citations
Open access Jul 2026

Base Editing Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of X-Linked Severe Combined Immunodeficiency

It is concluded from preliminary data that gene therapy using BE HSPCs appear very promising for achieving an earlier and more robust multi-lineage immune reconstitution in adult patients using BE HSPCs.

S. S. de Ravin, Michelle Ma, Yuzhi Yin et al. · 0 citations

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