Author

Diane S. Krause

2 papers indexed here

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Review Open access Sep 2026

RBM15 in leukemogenesis: an emerging regulator at the interface of RNA biology and hematopoiesis

RNA-binding motif protein 15 (RBM15) is a key regulator of hematopoiesis and leukemogenesis, linking RNA metabolism, epitranscriptomic regulation, and lineage specification. Identified through the RBM15::MKL1 fusion in acute megakaryoblastic leukemia (AMKL), RBM15 functions within the N6-methyladenosine (m6A) writer co...

Jether Amos Espinosa, Madeline Y. Mayday, Abigail R. Robb et al. · Trends in Cancer · 0 citations

#gene editing Open access Sep 2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

The results reveal a unique human mechanism of disease and offer therapeutic insight for this inflammasomopathy and CRISPR editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) led to very efficient and persistent gene deletion in vivo.

Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al. · Journal of Clinical Investig... · 0 citations