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Author

Dharani Sen

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2026

Design to Neuroprotection: A Blood Brain Barrier Permeable Selective HDAC3 Inhibitor Active against Chemical and Viral Insults

Neuronal loss in neurodegenerative diseases is mediated by oxidative stress, neuroinflammation, and epigenetic dysregulation, with histone deacetylase 3 (HDAC3) playing a central role in inflammatory signaling and neuronal damage. We...

Darakhshan Begum, Sanjeev Regula, Suryansh Sengar et al. · 0 citations
Open access Aug 2026

Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors

Histone deacetylase 8 (HDAC8) has emerged as a promising therapeutic target due to its role in epigenetic regulation. In this study, novel non-hydroxamate-based quinoline analogues were designed and explored as HDAC8-selective inhibitors that exhibit nanomolar HDAC8 enzymatic inhibition. Notably, compounds BHC-10 and B...

N. V. M. Rao Bandaru, Vandana Joshi, M. Schweipert et al. · 0 citations

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