Engineering stem cell-derived islets for type 1 diabetes: genetic strategies for immune evasion and stress resilience.
Type 1 diabetes (T1D) is characterized by autoimmune-mediated destruction of pancreatic β-cells, resulting in lifelong insulin dependence and disease burden. Stem cell-derived islet (SCI) replacement therapies have emerged as a promising strategy to restore endogenous insulin production; however, immune rejection, infl...
Caterra Leavens, Connie S. Chamberlain, Deep H. Kapadia et al.
· Regenerative medicine · 0 citations