Da-Wei Huang

UpTCR: a unified progressive knowledge transfer foundation model for robust T-cell receptor-antigen binding recognition

T-cell receptor (TCR) recognition of antigenic peptides presented by human leukocyte antigen (HLA) molecules underpins adaptive immunity and T cell-based immunotherapy. However, the scarcity of complete interaction data and TCR cross-reactivity challenge robust prediction. Here, we present UpTCR, a unified progressiv...