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Author

Da-Peng Zhou

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Open access Aug 2026

Structural Basis of a High-Affinity Antibody Binding to Glycoprotein with Glycocalyx Decay

Cancer-associated defects in mucin-type O-glycosylation expose truncated glycans on cell-surface glycoproteins and create tumor-associated glycopeptide epitopes. However, the structural principles by which antibodies recognize specific MUC1 glycopeptide sequences remain incompletely defined. Here, we report the molecul...

Yun-Bin Han, Jun Niu, Deng Pan et al. · 0 citations
#gene editing Open access Oct 2026

Gene dosage effect and reduced core fucosylation in B lymphocytes of FUT8 heterozygous mice

Core fucosylation (alpha1,6-fucosylation) of N-glycans, catalyzed solely by fucosyltransferase 8 (FUT8), plays important roles in development, immunity, and antibody effector functions. Here we report the generation of Fut8 floxed mice using a CRISPR/Cas9-based Extreme Genome Editing (EGE) system, in which loxP sites f...

Yue Ma, Jing-Xia Wang, Jing-Qing Liu et al. · 0 citations

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