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Author

D. Rujescu

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5 papers indexed here

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Open access Sep 2026

Network-specific metabolic cost of functional connectivity in the human brain

Despite decades of extensive research, the complex architecture underlying human brain signaling remains incompletely understood. Previous work investigating the relationship between brain glucose metabolism and functional connectivity (FC) employed whole-brain analysis, without accounting for network interactions, dep...

Sarah M. Tüchler, P. Falb, C. Milz et al. · 0 citations
Open access Sep 2026

653. Effects of 10Hz transcranial focused ultrasound stimulation at the posterior cingulate cortex on cerebral glucose metabolism – a pilot fPET study

Abstract Background Transcranial focused ultrasound stimulation (TUS) is emerging as a promising method for non-invasive and safe modulation of neuronal activity throughout the human brain [1]. Although several centers worldwide have started to investigate TUS in patient collectives, dosing of sonication parameters rem...

G. Godbersen, M. Lückel, C. Milz et al. · 0 citations
Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · 0 citations
Open access Sep 2026

557. ECT-induced effects on brain structure, brain connectivity and cerebrospinal-fluid-based markers – a preliminary analysis

Abstract Background Electroconvulsive therapy (ECT) is among the most effective treatments for severe and treatment-resistant depression. Despite more than 90 years of clinical use, its underlying neurobiological mechanisms remain incompletely understood. One prominent hypothesis suggests that ECT induces neuroplastic...

P. Baldinger-Melich, S. Riessland, B. Spurny-Dworak et al. · 0 citations
Aug 2026

Distinguishing different psychiatric disorders using DDx-PRS

Despite great progress on case–control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis–polygenic risk...

W. Peyrot, G. Panagiotaropoulou, L. O. Olde Loohuis et al. · 0 citations

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