Author

Colm J. Ryan

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Open access Sep 2026

PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

Most Triple Negative Breast Cancers (TNBCs) are p53 mutant high-grade invasive ductal carcinomas with a basal-like transcriptional programme. A large proportion of TNBCs also have mutation signatures indicating defective homologous recombination (HR) DNA repair. While HR deficiency is mutagenic and oncogenic, it can al...

V. Amodeo, D. Weekes, Nicolae Balan et al. · Nature Communications · 0 citations

Open access Sep 2026

Systematic prioritisation of context-specific paralog pair vulnerabilities in cancer

Genome-wide CRISPR screening has enabled the development of dependency maps in hundreds of cancer cell lines, facilitating the identification of genetic vulnerabilities associated with specific biomarkers and supporting precision oncology efforts. However, current dependency maps largely capture single-gene effec...

Narod Daldal, Hamda Ajmal, David J. Adams et al. · Genome Medicine · 0 citations

#gene editing Review Open access Aug 2026

A survey of multi-targeting and off-targeting sgRNAs across five genome-wide CRISPR-Cas9 knockout sgRNA libraries with GuideRefine

It is confirmed that multi-targeting sgRNAs disproportionately impair cell fitness and that sgRNAs aligning to more than one location with a single mismatch can also reduce fitness, although to a lesser extent.

S. Bernard, M. Rainey, Corrado Santocanale et al. · bioRxiv · 0 citations