Author

Chun-Jun Guo

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Open access Aug 2026

Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility

The intestinal epithelium is exposed to diverse combinations of microbiota-derived compounds; however, the mechanisms by which the host integrates these signals remain poorly defined. Studying two highly abundant microbial metabolites, we identified the purine metabolite hypoxanthine as an effector metabolite that dire...

Yang Xiao, T. Louwies, R. Mars et al. · Proceedings of the National... · 0 citations

Aug 2026

Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production.

This work identifies a panel of strong constitutive promoters that drive robust gene expression across diverse clostridial strains and develops an inducible promoter system that enables precise, tunable gene regulation and facilitates the implementation of CRISPR-Cas gene-deletion systems.

Ting-Ting Li, Xi Chen, Fang Wang et al. · Nature Biotechnology · 0 citations