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Author

Christopher Handelmann

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Aug 2026

maniFasta and the AllOralsDB: simplifying construction of comprehensive reference databases for metaproteomics

ManiFasta is presented, a tool enabling users to generate standardized, reproducible, and robustly documented protein reference sets from diverse input sources and datatypes, and the value of maniFasta is highlighted in the context of salivary metaproteomics, addressing the need for a taxonomically comprehensive refere...

Christopher Handelmann, Ashley K. Miles, Yin-Yin Ye et al. · 0 citations
#gene editing Open access Aug 2026

Evaluating high-fidelity CRISPR-Cas nucleases in nucleosomal contexts using a quantitative framework

It is demonstrated that local nucleosome sequence and structure profoundly influence Cas nuclease accessibility and specificity, with HIFIv1 emerging as the top-performing nuclease for nucleosomal targets, while evoSpCas9 excelled in exposed contexts.

Christopher Handelmann, Erin Skeens, George P. Lisi et al. · 0 citations

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