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Background: Volumetric muscle loss (VML) significantly impairs the inherent regenerative ability of skeletal muscle, causing dysfunction and scar tissue formation. Current treatments are limited to functional muscle transplantation, posing many complications and incomplete functional recovery. Methods: To simulate the...
Tumor-associated macrophages (TAMs) adapt to hypoxia, nutrient competition, lipid accumulation, and anticancer treatment. Mitochondria contribute to this adaptation through energy metabolism, redox signaling, mitochondrial DNA (mtDNA) sensing, and metabolite-dependent regulation of gene expression. This Review examines...
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