Urine-derived induced pluripotent stem cells for non-invasive diagnosis of bladder cancer
The biological rationale, reprogramming methodology, and diagnostic potential of urine-derived iPSCs (UDiPSCs) in the context of BLCA detection and monitoring are reviewed and a tiered strategy in which methylation is assessed in parental urinary cells, genomic variants in reprogrammed clones, and transcriptional pheno...