Results indicate substantial cross-ancestry sharing of breast cancer polygenic architecture, highlight a consistent contribution of regulatory variation, and identify convergent cellular contexts that motivate functional follow-up and inform expectations for the transferability and attainable performance of common-vari...
James L. Li, Maria Zanti, Jacob Williams et al.· JNCI Cancer Spectrum· 0 citations
A comprehensive analysis of 60 CIMs provides limited evidence supporting broad causal effects of circulating inflammatory markers contributing to variation in MD phenotypes, although most instruments demonstrated weak conditional instrument strength after inclusion of BMI.
A. H. Suger, T. Harrison, C. Haas et al.· medRxiv· 0 citations
Decaffeinated coffee was associated with lower risk of all-cause mortality, and caffeine was associated with lower risk of all-cause and CRC-specific mortality.
Kathryn R. K. Benson, Irina Tolstykh, June M. Chan et al.· Cancer Causes and Control· 0 citations
A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.
L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al.· Nature Communications· 0 citations
Increasing PM2.5, NO2, NOx, and CO exposures were suggestively associated with increased CRC incidence, particularly among female and Latino participants and for left colon and rectal cancers.
U. Ihenacho, Chiu‐Cheng Tseng, Jun Wu et al.· Environmental Research· 0 citations
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