Author

C. Beeche

3 papers indexed here

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Open access Aug 2026

A Computational and Statistical Framework Leveraging AI-Derived CT Phenotypes for Causal Mediation Effects Between Genetic Variants and Disease

As the costs of genetic sequencing continue to drop and human genomic biobanks grow in scale, the challenge in genomics has shifted increasingly towards disentangling whether and how associated genetic variants cause disease. Clinical imaging in health-system-based biobanks provides quantitative physiological measures...

K. Keat, D.-Y. Zhang, L. Caruth et al. · medRxiv · 0 citations

Open access Sep 2026

Generalizable CT vision-language modeling for population health and disease risk

Percival is introduced, a CT-native VLM trained on more than 400,000 CT-report pairs from the Penn Medicine BioBank using a dual-encoder symmetric contrastive framework, and evaluated against alternative foundation-model paradigms, indicating that CT-VLMs uncover latent structure aligned with clinical, physiological, a...

C. Beeche, Joonghyun Kim, H. Tavolinejad et al. · npj Digital Medicine · 1 citation

Review Aug 2026

ETHOS: Towards a Modular Ethics Framework for Clinical Multi-Agent Systems

ETHOS (Ethics and Trust through Hierarchical Oversight System), a modular ethics framework designed as a governance meta-agent that can be integrated with any existing multi-agent system without requiring changes to its underlying architecture, is presented.

Rakesh Sharma, S. Pugh, C. Beeche et al. · 0 citations