Author

C. B. Scarim

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Open access Oct 2026

Antifungal Activity and Safety of Physalis angulata Extract, Its Fraction, and Their Nanoemulsions as Candidate Cosmetic Ingredients: A Preliminary In Vitro Study

Physalis angulata L. is a source of lipophilic bioactive metabolites of interest for cosmetic research, but the antifungal behavior of its fractions in nanoemulsions remains poorly characterized. This study evaluated the antioxidant, antifungal, irritant, and cytotoxic activity of a chloroform extract (E) and a hexane–...

C. C. B. Medeiros, R. Sorrechia, Maria Leonor Beneli Donadon et al. · Cosmetics · 0 citations

#gene editing Review Open access Aug 2026

Epigenetic strategies for fetal hemoglobin induction in sickle cell disease.

This review discusses medicinal chemistry approaches primarily targeting HDAC1/2, LSD1, and DNMT1, with emphasis on inhibitor classes, binding mechanisms, structural features, preclinical evidence, and translational limitations, and how a better understanding of γ-globin repression may guide the development of safer an...

Mateus Mello de Souza, A. R. Pavan, Victor Gabriel de Faria Pastre et al. · European journal of medicina... · 0 citations