Aug 2026
In vivo genome-wide CRISPR screens of human T cells in solid tumours
Qi Liu, P. Chen, Esha Urs et al.
· Nature · 2 citations
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Programming primary human T cells to deliver gene editing machinery
Clinical applications of gene editors including CRISPR-Cas9 are limited by the cell-type specificity and tissue penetrance of current in vivo delivery options. Cell-mediated gene editor delivery could overcome these obstacles. To date, systems utilizing immortalized cell lines have demonstrated gene editor delivery in...
James Meixiong, Oleksandr Zginnyk, Lauren Chow et al.
· bioRxiv · 0 citations
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
A virus-like particle (VLP)-based toolkit that delivers diverse CRISPR editing modalities to human monocytes, macrophages and dendritic cells with high efficiency while preserving viability and innate immune responsiveness is presented.
Hyuncheol Jung, Pascal Devant, Carter Ching et al.
· Nature Biotechnology · 0 citations